Jeffrey Henderson Profile
BA 1991 Science/Mathematics (Biology), Judson University
PhD 1998 Molecular Genetics, The Ohio State University
Dissertation topic: Structure-Function Analysis of the Herpes Simplex Virus Type 1 UL12 Gene.
Before joining the faculty at his alma mater, Dr. Henderson conducted research at Washington University School of Medicine (WUSM), Kansas State University and taught biology at two other small Christian liberal arts institutions. He responded to God’s call into Christian higher education while a postdoctoral fellow at WUSM and is very excited that God’s plans have lead him back to Judson. He is committed to having a rigorous and intellectually challenging biology curriculum presented in the environment of a Christ-centered classroom.
Expertise / Involvements
Molecular Biology, Molecular Genetics, Cancer Biology
Research Scientist, Department of Biology, Kansas State University, Manhattan, KS, 2009-2010. Biochemical and molecular biological analysis of α- & γ-crystallins in cataractogenesis.
Staff Scientist, Division of Molecular Oncology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, 2008-2009. Cell biology of p53 and ARF in breast cancer.
Postdoctoral Research Fellow, Division of Gastroenterology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, 1998-2003. Studies on the role of RNA-binding proteins in colon cancer and atherosclerosis.
Henderson JO and Takemoto, LJ. 2012. Lens Plasticity and Intralenticular Translocation of Crystallins. In: Advances in Eye Research, Vol. 2 (W.L. Thomsen, editor), Nova Science Publishers, New York, pp. 215-222.
Blanc V, Henderson JO*, Newberry RD, Xie Y, Cho S-J, Newberry EP, Kennedy S, Rubin DC, Wang HL, Luo J, Davidson NO. Deletion of the AU-rich RNA binding protein apobec-1 reduces intestinal tumor burden in Apcmin mice. Cancer Res. 2007 Sep 15;67(18):8565-73. * Equal contribution
Bishnupuri KS, Luo Q, Korzenik JR, Henderson JO, Houchen CW, Anant S, Dieckgraefe BK. Dysregulation of Reg gene expression occurs early in gastrointestinal tumorigenesis and regulates anti-apoptotic genes. Cancer Biol. Ther. 2006;5(12):1714-20. Epub Dec. 2006.
Blanc V, Henderson JO, Newberry EP, Kennedy S, Luo J, Davidson NO. Targeted deletion of the murine apobec-1 complementation factor (Acf) gene results in embryonic lethality. Mol. Cell Biol. 2005 Aug;25(16):7260-9.
Bannerjee B, Henderson JO, Chaney TC, Davidson NO. Detection of murine intestinal adenomas using targeted molecular autofluorescence. Dig. Dis. Sci. 2004 Jan;49(1):54-9.
Anant S*, Henderson JO*, Mukhopadhyay D, Min J, Kennedy SM, Davidson NO. Novel role for RNA binding protein CUGBP2 in mammalian mRNA editing: CUGBP2 modulates C to U editing of apolipoprotein B mRNA by interacting with apobec-1 and ACF, the apobec-1 complementation factor. J. Biol. Chem. 2001 Dec 14;276(50):47338-51. Epub 2001 Sep 27. * Equal contribution
Blanc V, Henderson JO, Kennedy S, Davidson NO. Mutagenesis of apobec-1 complementation factor reveals distinct domains that modulate RNA binding, protein-protein interaction with apobec-1, and complementation of C to U RNA-editing activity. J. Biol. Chem. 2001 Dec 7;276(49):46386-93. Epub 2001 Sep 24.
Anant S, Mukhopadhyay D, Sankaranand V, Kennedy S, Henderson JO, Davidson NO. ARCD-1, an apobec-1-related cytidine deaminase, exerts a dominant negative effect on C to U RNA editing. Am. J. Physiol. Cell Physiol. 2001 Dec;281(6):C1904-16.
Henderson JO, Blanc V, Davidson NO. Isolation, characterization and developmental regulation of the human apobec-1 complementation factor (ACF) gene. Biochim. Biophys. Acta(Gene Structure and Expression) 2001 Nov 11;1522(1):22-30.
Blanc V, Navaratnam N, Henderson JO, Anant S, Kennedy S, Jarmuz A, Scott J, Davidson NO. Identification of GRY-RBP as an apolipoprotein B RNA binding protein that interacts with both apobec-1 and with apobec-1 complementation factor (ACF) to modulate C to U editing. J. Biol. Chem. 2001 Mar 30;276(13):10272-10283. Epub 2000 Dec 27.
Henderson JO, Ball-Goodrich LJ, Parris DS. Structure-function analysis of the herpes simplex virus type 1 UL12 gene: correlation of deoxyribonuclease activity in vitro with replication function. Virology. 1998 Mar 30;243(1):247-59.
Professional Societies or Affiliations
American Association for the Advancement of Science
American Scientific Affiliation
American Society for Microbiology
Genetics Society of America
My lab is currently involved in the molecular cloning and expression of a novel RNA-binding protein expressed during brain development.