Directory

He responded to God’s call into Christian higher education while a postdoctoral fellow at WUSM and is very excited that God’s plans have lead him back to Judson.  He is committed to having a rigorous and intellectually challenging biology curriculum presented in the environment of a Christ-centered classroom.

• BA   1991   Science/Mathematics (Biology), Judson University
• PhD 1998   Molecular Genetics, The Ohio State University
• Dissertation topic: Structure-Function Analysis of the Herpes Simplex Virus Type 1 UL12 Gene.

Molecular Biology, Molecular Genetics, Cancer Biology

Research Scientist, Department of Biology, Kansas State University, Manhattan, KS, 2009-2010. Biochemical and molecular biological analysis of α- & γ-crystallins in cataractogenesis.

Staff Scientist, Division of Molecular Oncology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, 2008-2009.  Cell biology of p53 and ARF in breast cancer.

Postdoctoral Research Fellow, Division of Gastroenterology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, 1998-2003.  Studies on the role of RNA-binding proteins in colon cancer and atherosclerosis.

†Cisneros, A. and Henderson, J.O. (2021). Kearns Sayre Syndrome: A Mitochondrial Disorder. J. of Student Res. 10(1).

†Kennedy, A.J. and Henderson, J.O. (2019). Using CRISPR-Cas9 technology to create cancer therapeutics. J. of Student Res. 8(1), 62-70.

†*Price, L.E., †*Faul, A.B.L., †Vuchkovska, A., †Lopez, K.J., †Fast, K.M., †Eck, A.G., Hoferer, D.W., and Henderson, J.O. (2019). Molecular Genetic Analysis of Rbm45/Drbp1: Genomic Structure, Expression, and Evolution. J. of Student Res. 7(2), 49-61. * Equal contribution

†*Eck, A.G., †*Lopez, K.J., and *Henderson, J.O. (2018). RNA-binding motif protein 45 (Rbm45)/Developmentally regulated RNA-binding protein-1 (Drbp1): Association with neurodegenerative disorders. J. of Student Res. 7(2), 33-37. * Equal contribution

†*Hetrick, K.M., Juergensmeyer, E.A., and *Henderson, J.O. (2018). Analysis of Escherichia coli flagellin gene expression in simulated spaceflight growth conditions. J. of Student Res. 7(1), 50-53. * Equal contribution

†Romesberg, J. and Henderson, J.O. (2018). Analysis of total coliform and total Escherichia coli levels in the Fox River watershed. J. of Student Res. 6(2), 66-70.

†Kennedy, A.J. and Henderson, J.O. (2018). Angelman syndrome: an autism spectrum disorder. J. of Student Res. 6(2), 56-60.

†Schieler, J.M. and Henderson, J.O. (2016). Treating a dysregulated JAK/STAT pathway in cancer cells. J. of Student Res. 5(1), 11-17.

†Horgan, K.J. and Henderson, J.O. (2015). Resistance genes of Oryza sativa for protection against Xanthomonas oryzae pv. Oryzae, the causative agent of bacterial leaf blight. J. of Student Res. 4(1), 12-17.

†Horgan, K.J. and Henderson, J.O. (2015). miRNA mediated posttranscriptional gene regulation in response to abiotic stress in plants. J. of Student Res. 4(1), 21-28.

†Lopez, K.J. and Henderson, J.O. (2015). Yeast Ssu72 protein as a mediator of gene loop formation at bidirectional promoters. J. of Student Res. 4(1), 29-35.

Henderson JO and Takemoto, LJ. 2012.  Lens Plasticity and Intralenticular Translocation of Crystallins. In: Advances in Eye Research, Vol. 2 (W.L. Thomsen, editor), Nova Science Publishers, New York, pp. 215-222.

Blanc V, Henderson JO*, Newberry RD, Xie Y, Cho S-J, Newberry EP, Kennedy S, Rubin DC, Wang HL, Luo J, Davidson NO. Deletion of the AU-rich RNA binding protein apobec-1 reduces intestinal tumor burden in Apcmin mice. Cancer Res. 2007 Sep 15;67(18):8565-73.     * Equal contribution
Bishnupuri KS, Luo Q, Korzenik JR, Henderson JO, Houchen CW, Anant S, Dieckgraefe BK. Dysregulation of Reg gene expression occurs early in gastrointestinal tumorigenesis and regulates anti-apoptotic genes. Cancer Biol. Ther. 2006;5(12):1714-20. Epub Dec. 2006.

Blanc V, Henderson JO, Newberry EP, Kennedy S, Luo J, Davidson NO. Targeted deletion of the murine apobec-1 complementation factor (Acf) gene results in embryonic lethality. Mol. Cell Biol. 2005 Aug;25(16):7260-9.

Bannerjee B, Henderson JO, Chaney TC, Davidson NO. Detection of murine intestinal adenomas using targeted molecular autofluorescence.  Dig. Dis. Sci. 2004 Jan;49(1):54-9.

Anant S*, Henderson JO*, Mukhopadhyay D, Min J, Kennedy SM, Davidson NO. Novel role for RNA binding protein CUGBP2 in mammalian mRNA editing: CUGBP2 modulates C to U editing of apolipoprotein B mRNA by interacting with apobec-1 and ACF, the apobec-1 complementation factor. J. Biol. Chem. 2001 Dec 14;276(50):47338-51. Epub 2001 Sep 27.     * Equal contribution

Blanc V, Henderson JO, Kennedy S, Davidson NO. Mutagenesis of apobec-1 complementation factor reveals distinct domains that modulate RNA binding, protein-protein interaction with apobec-1, and complementation of C to U RNA-editing activity.  J. Biol. Chem. 2001 Dec 7;276(49):46386-93. Epub 2001 Sep 24.

Anant S, Mukhopadhyay D, Sankaranand V, Kennedy S, Henderson JO, Davidson NO.  ARCD-1, an apobec-1-related cytidine deaminase, exerts a dominant negative effect on C to U RNA editing. Am. J. Physiol. Cell Physiol. 2001 Dec;281(6):C1904-16.

Henderson JO, Blanc V, Davidson NO.  Isolation, characterization and developmental regulation of the human apobec-1 complementation factor (ACF) gene. Biochim. Biophys. Acta (Gene Structure and Expression) 2001 Nov 11;1522(1):22-30.

Blanc V, Navaratnam N, Henderson JO, Anant S, Kennedy S, Jarmuz A, Scott J, Davidson NO.  Identification of GRY-RBP as an apolipoprotein B RNA binding protein that interacts with both apobec-1 and with apobec-1 complementation factor (ACF) to modulate C to U editing. J. Biol. Chem. 2001 Mar 30;276(13):10272-10283. Epub 2000 Dec 27.                                                                                                                                                                      

Henderson JO, Ball-Goodrich LJ, Parris DS. Structure-function analysis of the herpes simplex virus type 1 UL12 gene: correlation of deoxyribonuclease activity in vitro with replication function. Virology.  1998  Mar 30;243(1):247-59.

• American Association for the Advancement of Science
• American Scientific Affiliation
• American Society for Microbiology
• Genetics Society of America

My lab is currently involved in the molecular cloning and expression of a novel RNA-binding protein expressed during brain development.